Warriors called "Saints" are the champions of hope who have always appeared since the Age of Myth whenever evil threatens the world. In this present day story, many years since the long fought "Holy War" we find Saori Kido, a girl troubled by her mysterious powers. She is saved by a boy, Seiya "Bronze Saint" from a sudden attack by an assassin, through the accident Saori realizes her destiny and mission and decides to go to "Sanctuary" with Seiya and his company of Bronze Saints. In Sanctuary they confront "Pope" and wage a desperate battle against the greatest Saints, the "Gold Saints".
The plot involves the coming of Lucifer to the Sanctuary, where his underlings systematically dispose of the surviving Gold Saints. Athena goes to Lucifer to ask for peace, placing herself in peril. The Bronze Saints must then come to her rescue, destroying Lucifer's Fallen Angels (Seima Tenshi in Japanese) in the process.
After the Saints' victory against Hades, Seiya is left wounded and motionless in a wheel chair with no possible chance of recovery. Athena's sister Artemis, the Virgin Goddess of the Moon and twin sister of Apollo, makes an elaborate proposal - to restore Seiya's physical health in exchange for the supremacy of Sanctuary. Athena accepts and Artemis and her "Knights of the Sky" swiftly take control of Sanctuary. Now Seiya and his fellow Bronze Saints combat the forces of Zeus to regain their homeland but it will not be so easy. Bronze Saints Hydra Ichi and Unicorn Jabu, and Silver Saint Ophiuchus Shaina have join forces with Artemis and Apollo.
Athena receives the visit of Phoebus Abel, her older brother and God of the Corona. He informs her that he has come to destroy humanity as punishment for their corruption, just as it was done in ancient times. He dismisses Seiya and the Bronze Saints, as she will now be guarded by Abel's three Corona Saints, Atlas of Carina, Jaow of Lynx and Berenike of Coma Berenices, and the five resurrected Gold Saints who died in the Sanctuary battle: Saga of Gemini, Deathmask of Cancer, Shura of Capricorn, Camus of Aquarius and Aphrodite of Pisces. When Athena rebels against Abel's plan, he attacks her, sending her soul to Elysion, the final resting place from which there is no return. The Bronze Saints immediately rush to the Sanctuary to save her and ultimately overcome Abel.
In Siberia, Hyōga saves a man that is being attacked. Injured, the man manages only to say something about Asgard. Some days later, Saori, Seiya, Shiryū and Shun are wondering about Hyōga and decide to go to Asgard to investigate. At Valhalla, the Lord of Asgard, Dolbar, says he has not heard of any Hyōga and neither has his right hand, Loki. However, at all times Seiya and the others can feel an evil cosmo emanating from Loki and the other Odin Saints called God Warriors. Shiryū, in particular, notices a familiar cosmo coming from Midgard, a mysterious, masked God Warrior. Dolbar makes it clear that he is trying to take control of both Asgard and the Sanctuary, imprisoning Athena in a strange dimension within the giant statue of Odin. Midgard reveals himself as Hyōga and tries to kill Shiryū to prove himself to Dolbar. Thus, it is the task of the Bronze Saints to defeat Dolbar, Loki and the rest of the God Warriors, to save Athena and Hyōga.
When Seiya, Hyōga and Shun visit Saori (Athena) at the orphanage, they meet an employee called Eri. An orphan herself, Eri takes a liking to Hyōga and one night they sit outside watching the stars. They see a shooting star and Hyōga asks Eri to make a wish. After Hyōga leaves, however, Eri becomes powerfully attracted to the shooting star and wanders alone into the woods, where she finds a golden apple. She is then possessed by Eris, the Goddess of Discord, and kidnaps Athena, planning to use the golden apple to suck her energy out, fully reincarnate and take over the world. Eris leaves a message for the Bronze Saints, who set out for the goddess's temple which appears on the mountains. There, the heroes fight the five Ghost Saints: Maya of Sagitta, Orpheus of Lyra, Christ of the Southern Cross, Jan of Scutum (called by the Japanese name Tateza) and Jäger of Orion.
After the 12 Gold Saints sacrifice their lives to destroy the Wailing Wall, the Bronze Saints enter the deepest realm of the Underworld, Elysion, where they face off aganist Hades's two most powerful servants, The Twin Gods, Hypnos and Thanatos, before they can reach Hades for the final battle.
Ages ago, the goddess Athena was served by fighters called Saints who channeled the power of the Cosmos within them. Now a youth named Seiya has trained to become a Saint himself by earning the mystical Cloth of Pegasus. He is joined by other Saints with Cloths of their own to fight for Athena.
Saint Seiya Omega is an anime series produced by Toei Animation. It is a spin-off based on the Saint Seiya manga series written and illustrated by Masami Kurumada, produced in commemoration of the 25th anniversary of the franchise. The series began broadcasting in Japan on TV Asahi on April 1, 2012. It is being directed by Morio Hatano, with animation character designs by illustrator and animator Yoshihiko Umakoshi, known for performing the same duties on Street Fighter Alpha: The Animation, HeartCatch PreCure! and Casshern Sins. Toei Animation describes it as an "original anime story", separate from the continuity of Kurumada's manga. Original Saint Seiya author Kurumada is not involved in the creative process of Omega, thus he is credited as the original creator of the series' concept.
After the 12 Gold Saints sacrifice their lives to destroy the Wailing Wall, the Bronze Saints enter the deepest realm of the Underworld, Elysion, where they face off against Hades's two most powerful servants, The Twin Gods, Hypnos and Thanatos, before they can reach Hades for the final battle.